mpr [2017-05-24 16:06:33]

extracellular metalloprotease

locus: BSU02240

pI: 8.97

mw: 33.69 kDa

protein length: 313 aa

gene length: 939 bp

function: protein degradation

product: extracellular metalloprotease

essential: no

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.3|Utilization of nitrogen sources other than amino acids] → [category|SW 2.3.3.5|Utilization of proteins]
• [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.7|Proteolysis] → [category|SW 3.3.7.2|Extracellular feeding proteases]
• [category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins]

Gene

Coordinates: 245,190 → 246,131

The protein

Protein family

• peptidase S1B family (according to Swiss-Prot)

[SW|Localization]

• extracellular (signal peptide) [Pubmed|18957862]

Expression and Regulation

Operons

• genes: [gene|A39D349BBE13F4F3F6D33DA72CB8149A5170255C|mpr]-[gene|22A5905A0C2A9303C166A5C2D784AF0B6541A311|ybfJ]
  description: [Pubmed|12107147]

  regulatory mechanism

  • [protein|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|CodY]: repression, [Pubmed|25666135], in [regulon|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|CodY regulon]

  regulation

  • repressed by casamino acids [Pubmed|12107147]

Biological materials

Mutant

• BKE02240 (''Δmpr::erm trpC2''), available at BGSC
• KO7 (''ΔnprE ΔaprE Δepr Δmpr ΔnprB Δvpr Δbpr''), available as BGSC 1A1133

References

Reviews

• 20735481

Original publications

• 15375126,24115457,18957862,12107147,25666135